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We have an opening for a fully funded PhD position at the Institut de Biologie Structurale in Grenoble, France, to study the structural dynamics of vitamin B12-dependent photoreceptors by time-resolved X-ray crystallography and time-resolved cryo-electron microscopy in view of biotechnological applications.
This integrated structural biology project aims at understanding the activation mechanism of the recently discovered family of vitamin B12-dependent photoreceptors. In particular, we aim at visualising protein conformational changes upon photoactivation from the photochemical (picoseconds) to the photobiological timescales (milliseconds-seconds). To do so, we use time-resolved crystallography at X-ray free electron lasers (Rios-Santacruz et al, 2026) and at synchrotrons and time-resolved cryo-electron microscopy. By establishing the modus operandi of these newly discovered B12 photoreceptors this PhD project will open windows to their rational modification for biotechnological exploitation as optogenetic components.
We welcome applications from students trained in protein biophysics, and preferably in crystallography or electron microscopy.
For further information and to apply, please contact either Martin Weik (weik@ibs.fr) or Giorgio Schirò (giorgio.schiro@ibs.fr). The deadline for applications is April 10 2026.
Recent publication by the group and relevant to the PhD project.
