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We are looking for a highly motivated postdoctoral candidate with cryoEM training to join the JP lab at the University of Edinburgh to discover non-canonical mechanisms of genome transfer in a clinically relevant human fungal pathogen, Cryptococcus neoformans, as part of a Wellcome Discovery Award-funded research program.
Cryptococcus neoformans is an understudied environmental yeast, designated the most critical priority human fungal pathogen by the World Health Organisation (WHO). Mostly immunocompromised patients succumb to Cryptococcal infections, causing ~147,000 deaths in AIDS patients. This will be a highly interactive and collaborative study with the groups of Prof. Hardwick at the University of Edinburgh and Prof. Sanyal at JNCASR, Bengaluru.
The project will involve dissecting the mechanisms that regulate chromosome segregation and cell division using a range of structural biology, biochemical, and biophysical methods, complemented by yeast genetics and cell biology (in collaboration with the Profs. Hardwick and Sanyal labs). The position is initially fixed-term for 36 months and is ideally suited for ambitious, motivated, and creative individuals.
The candidate will benefit from excellent core resources, including a state-of-the-art Glacios 2 electron microscope equipped with a Falcon 4i direct detector and a Selectris-X energy filter, as well as proteomics and light microscopy facilities.
For an overview of our recent research, see below:
Experience with single-particle Cryo-EM, protein biochemistry, and single-molecule biophysics is highly desirable. To apply for the position, please follow this link. Closing date 31 March 2026.
Informal enquiries from prospective candidates with their CV and a statement describing their research experience, scientific interest, career goals, and motivation are encouraged: ajeyapra@ed.ac.uk
