The research project involves structural studies of the ribonucleotide reductase family of enzymes and NrdR, their associated transcription factor in bacteria. In particular, we are interested in the role of the small, evolutionarily mobile nucleotide binding domain known as the ATP-cone in allosteric regulation of enzymatic activity and transcription. We use a combination of structural and biophysical techniques, including X-ray crystallography, cryo-electron microscopy, small-angle X-ray scattering, microscale thermophoresis etc. The project will also involve protein production in bacteria and purification and may involve some NMR studies.
The main duties of doctoral students are to devote themselves to their research studies, which includes participating in research projects and third cycle courses. The work duties will also include teaching and other departmental duties (no more than 20%).
